"Baking Soda (Sodium Bicarbonate) yopanda poizoni komanso yopanda vuto imayikidwa mu nano 'capsule' yotetezeka (liposome), ndipo tetracycline yokhala ndi mphamvu yomangira mafupa imayikidwa pamwamba kuti ilowe m'mafupa. Pamene ma osteoclast awononga minofu ya mafupa potulutsa asidi, amatha kutulutsa Sodium Bicarbonate nthawi yomweyo, zomwe zimalepheretsa ntchito ya ma osteoclast ndikukwaniritsa cholinga chopewa matenda a osteoporosis." Gulu lotsogozedwa ndi Pulofesa Shunwu Fan wa Dipatimenti ya Orthopedics, Run Run Shaw Hospital, Zhejiang University, ndi Pulofesa Ruikang Tang wa Dipatimenti ya Chemistry, Zhejiang University, posachedwapa adafalitsa zomwe adapeza mu Journal of the American Chemical Society.
Malinga ndi mawu oyamba, ma osteoclast ali ngati chiswe chomwe chili mumtengo, chomwe chimagwira ntchito kale, ngakhale mtengo wautali, komanso chifukwa cha kuwola ndi kugwa kwa nthawi yayitali. Kafukufuku waposachedwa akukhulupirira kuti chifukwa chachikulu cha osteoclast ndi kuyambitsa kwachilendo kwa ma osteoclast, ndipo kutulutsa asidi ndi ma osteoclast kumaonedwa kuti ndi chinthu chofunikira kwambiri pakuwonongeka kwa mafupa ndi ma osteoclast komanso chofunikira kwambiri kuti minofu ya mafupa iwonongeke.
Mankhwala akuluakulu omwe amagwiritsidwa ntchito pochiza matenda a osteoporosis amakwaniritsa cholinga choletsa kusungunuka kwa mafupa ndikulimbikitsa kusinthika kwa mafupa mwa kuyang'ana kwambiri pakuwongolera osteoclast kapena osteoblast biology, koma samapha gawo lofunikira kwambiri la chilengedwe cha asidi chakunja cha mapangidwe a osteoclast kuchokera ku gwero. Chifukwa chake, mankhwala omwe alipo amatha kuchepetsa kutayika kwa mafupa mwa okalamba mpaka pamlingo winawake, koma nthawi zambiri sangabwezeretse kwathunthu kuwonongeka kwa mafupa komwe kwachitika, ndipo kupereka mankhwala osakhala mafupa kungayambitsenso zotsatira zoyipa za ziwalo zomwe sizili pachiwopsezo komanso zina zoopsa.
Kuphatikiza apo, ngakhale kuti ma osteoclast ndi omwe amachititsa matenda a osteoporosis, kafukufuku wambiri wasonyeza kuti amachita nawo mbali polimbikitsa mapangidwe a mafupa ndi angiogenesis monga "maselo oyambira" asanatulutse asidi. Chifukwa chake, ndikofunikira kwambiri kuletsa ma osteoclast molondola.
Gulu la Fan Shunwu ndi gulu la Tang Ruikang ndi omwe adayambitsa njira yowunikira ma liposomes a Sodium Bicarbonate pamwamba pa mafupa, ndikupanga gawo loteteza la alkaline, kuletsa asidi wotulutsidwa ndi ma osteoclasts, kuletsa kuyambika kwa ma osteoclasts kosayenera, komanso kusintha mawonekedwe a malo ozungulira mafupa kuti akwaniritse zotsatira zochizira matenda a osteoporosis.
Lin Xianfeng, dokotala wa opaleshoni ya mafupa ku Run Run Shaw Hospital ku Zhejiang University, anati kafukufukuyu adapeza kuti zinthu za alkaline liposome ndi malo okhala ndi acidic a osteoclasts zimayambitsa kuchuluka kwa osteoclasts, ndipo adatulutsanso kuchuluka kwa ma vesicles akunja kwa thupi. "Zili ngati gulu la ma dominoes, omwe amakankhidwa gawo limodzi ndi limodzi ndikukulitsidwa sitepe imodzi ndi imodzi kuti athe kulimbana ndi kuwonongeka kwa mafupa komwe kumachitika chifukwa cha kulimba kwa osteoclasts."
Nthawi yotumizira: Januware-27-2021