"Baking Soda yopanda poizoni komanso yopanda vuto (Sodium Bicarbonate) yatsekedwa mu nano 'capsule' (liposome) yotetezeka, ndipo tetracycline yokhala ndi mphamvu yolimbitsa mafupa imakwera pamwamba kuti ifotokozere fupa. potulutsa asidi, amatha kutulutsa Sodium Bicarbonate nthawi yomweyo, kulepheretsa kugwira ntchito kwa mafupa komanso kukwaniritsa cholinga chopewa kufooka kwa mafupa. ” Gulu lotsogozedwa ndi Pulofesa Shunwu Fan wa department of Orthopedics, Run Run Shaw Hospital, Zhejiang University, ndi Professor Ruikang Tang a department of Chemistry, Zhejiang University, posachedwapa adafalitsa zomwe apeza mu Journal of the American Chemical Society.
Malinga ndi mawu oyambawa, ma osteoclast ali ngati chiswe mumtengo, kamodzi kogwira ntchito, ngakhale mtengo wokulirapo, komanso chifukwa cha kuwola kwanthawi yayitali ndikugwa. Kafukufuku wapano akukhulupirira kuti chomwe chimayambitsa kufooka kwa mafupa ndikumayambitsa ma osteoclast, ndipo kutsekemera kwa asidi kwa ma osteoclasts kumawerengedwa kuti ndichofunikira kwambiri pakuwononga mafupa ndi ma osteoclast komanso chofunikira chofunikira pakuchepetsa kwawo kwa mafupa.
Mankhwala akulu omwe amachiza matenda a kufooka kwa mafupa amakwaniritsa cholinga chotsutsana ndi mafupa komanso kulimbikitsa mafupa a anabolism poyang'ana kwambiri malamulo a osteoclast kapena osteoblast biology, koma samapha gawo loyambirira la asidi wakunja kwa mafupa a osteoclast ochokera ku gwero. Chifukwa chake, mankhwala omwe adalipo amatha kuchepetsa kuchepa kwa mafupa kwa okalamba mpaka pamlingo winawake, koma nthawi zambiri sangathe kusinthiratu kuwonongeka kwa mafupa komwe kwachitika, ndikusankha mosagwiritsa ntchito mankhwala osagwiritsa ntchito mafupa kumatha kubweretsanso kuzowononga zina ndi zina zoyipa za ziwalo.
Kuphatikiza apo, ngakhale kuti ma osteoclast ndi omwe amachititsa kufooka kwa mafupa, kafukufuku wambiri awonetsa kuti amatenga gawo polimbikitsa mapangidwe a mafupa ndi angiogenesis ngati "maselo otsogola" asanatulutse asidi. Chifukwa chake, ndikofunikira kuti tilepheretse bwino ma osteoclasts.
Gulu la a Fan Shunwu ndi gulu la a Tang Ruikang adapanga upangiri wa Sodium Bicarbonate liposomes mpaka mafupa, ndikupanga zoteteza zoteteza mchere, kutseketsa asidi obisika ndi ma osteoclast, kulepheretsa kuyambitsa kwaminyewa kwamitsempha yamagazi, ndikukhazikitsanso kuchuluka kwa mafupa kuti athetse matenda a kufooka kwa mafupa .
Lin Xianfeng, wochita opaleshoni ya mafupa ku Run Run Shaw Hospital ya Zhejiang University, adati kafukufukuyu adapeza kuti zida zamchere zamchere zamchere zamchere komanso malo amchere amtundu wa ma osteoclast adapangitsa kuchuluka kwa maopoptosis a mafupa, ndikupitilizabe kutulutsa matumba ena ochulukirapo. "Ili ngati ma domino a ma domino, omwe amaponyedwa kamodzi ndikukulitsa gawo limodzi kuti athane ndi kuwonongeka kwa mafupa komwe kumayambitsidwa ndi mafupa."
Post nthawi: Jan-27-2021